
COMBINE WEAPONS in the microscopic roguelite turret shooter with macroscopic depth. Survive 6 modes using an astounding array of turrets, perks, mutations and power-ups on this psychedelic journey to the heart of the abyss. Shmup Mode turns it into a vertical shoot 'em up!
Modeled estimate, not a reported figure. How we estimate →
Discounts
Every price cut of more than 20% we have observed, in each market that quoted one, with this game's chart position on either side of it. These are episodes, not a model: a sale is one event, and one event cannot tell you what the next one will do.
Reviews, worldwide (the counter carries no country): 0/day in the week to Aug 28 → 0.14/day in the week after.
Reviews, worldwide (the counter carries no country): 19/day in the week to Jul 16 → 0.14/day in the week after.
For scale, across Steam · Top Sellers · Brazil over the last 30 days: the 26 chart moves that followed a price cut of more than 20% went a median of 7 places towards #1, and the 2,400 moves with no price cut behind them went 2 away. One store, one chart, one country — it is the only place we have enough observations to say even that.
Prices outside the United States have been collected since 6 August 2026 and chart positions since 19 July 2026, so a cut older than that has no market to compare and a market that joined later has no history yet. Nothing here is converted between currencies.
About
Dive into the microscopic world, radiating with bioluminescent life and unspeakable horrors. Genome Guardian is a deeply-complex shooter that's easy to pick up but hard to master. Research permanent upgrades to survive a variety of microbes across 6 game modes, each with multiple "depths".
Pair DNA nucleotides Adenine (rapidfire), Cytosine (precision), Guanine (spread), Thymine (explosive) to discover wild hybrid bioweapons!
Bomb + Shotgun combines explosives with spread to create Blast Shotgun!
Bomb + Bomb doubles down on explosive power to make Bazooka!
Blast Shotgun + Shotgun forms the all-powerful Flak Cannon!

49 Turrets with unique strengths and functions
96 Perks to mix and match that drastically change how you play
75 Weapon & Turret Mods that can turn shots into sticky laser mines or bouncing fireballs
64 Mutations alter the challenges you face each run

20-minute Runs that can be continued in Endless Mode
75 Bassy Electronic Tunes that adapt to the current mood & intensity
Cosmetics like spider legs and tank tread
Accessibility Settings for colourblindness, motion sickness, and even arachnophobia!
100 Steam Achievements
Steam Trading Cards
Cloud Save
Plays great on Steam Deck!!!

Engagement
Reviews
Themes across 45 recent reviews and how positive each mention is. A keyword signal, not full sentiment analysis.
Reviews
Buy this game. Also buy Cell Command. Also buy Genome Guardian 2. Delete all of your other videogames. You won't need them anymore.
absolutely amazing, the dna + combined with the lack of movement makes this game truly great. Can't wait for the sequel!steam://launch/2891310/Dialog
good
Media

Related
Related
Price dynamics, follower growth, revenue and sales trajectories with interactive tooltips
This and every other Pro feature is free until October 20, 2026. A free account is all it takes.
Genres
Stats
All-time low is the lowest price we've recorded for this game since we started tracking it.
Languages: English
Hours played at review time, across 46 reviews with recorded playtime.
positive critical· bar length = how often the theme comes up
was kinda mid
This isn't usually my type of game, but I thought I would step outside of my comfort zone. I actually ended up really enjoying it. I liked the variety of weapons choices and upgrades. The science aspect is unique. I can definitely see myself coming back to play this again in the future.
Really just a fantastic game. Very simple and pretty complex at the same time. And the music makes things exciting as you get into the deeper levels. Plus just love the whole vibrant neon colors.
is gud, ja?
Fun Fun Fun
It's a fun game with high replay value but it's not worth $12 in my opinion. I would recommend getting it in the bundle with Nova Drift or Galactic Glitch if they still offer that one.
Boring not enough progression
Players by region
Where this game's players are, estimated from review languages.
Related
| Game | Estimated lifetime revenue | Reviews | Review score | Price |
|---|---|---|---|---|
| $1.2K | 15 | 100% | $3.50 | |
| — | 0 | — | — | |
| $570 | 3 | 67% | $7.99 | |
| $56 | 3 | 67% | $0.99 | |
| — | 0 | — | — | |
| — | 0 | — | — |
Related
| Game | Estimated lifetime revenue | Reviews | Review score | Price |
|---|---|---|---|---|
| $240.3K | 292 | 80% | $24.99 | |
| $240.3K | 1.5K | 64% | $4.99 | |
| $240.3K | 253 | 61% | $29.99 | |
| $240.3K | 781 | 80% | $9.99 | |
| $240.4K | 450 | 61% | $14.99 | |
| $240.2K | 420 | 84% | $8.95 |