Patient Zero: Plague Idle
Patient Zero: Plague Idle is an idle / incremental outbreak builder where you create the perfect pathogen through mutation trees, global infection, long-term upgrades, and new pathogen unlocks. Turn the world into your lab.
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Free-to-play
Revenue comes from in-game items and microtransactions, which our price-based model doesn't estimate. The player count below is how many people own it, not what they spent.
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About
About the game
CAN YOU DESTROY HUMANITY?
Micro-scale evolution. Macro-scale extinction.
Patient Zero is an idle/incremental pandemic strategy where you engineer ever-evolving biological threats. As the architect of collapse, min-max your mutation layers to ensure the world succumbs to your design.
THE LOOP OF DESTRUCTION
Master a progression cycle built for massive scaling:
Harvest: Gather Biomass to fuel expansion.
Automate: Maximize your infection per second (IPS).
Mutate: Spend Genetic Capital on synergistic evolution trees.
Transcend: Use Prestige Layers to unlock meta-progression and resilient strains.
STRATEGIC MUTATION & SCALING
Navigate a vast Mutation Tree where every choice impacts global power. Balance stealth with lethality to overcome medical research and trigger an unstoppable snowball effect across extreme climates.
GLOBAL OUTBREAK SIMULATION
Watch the map turn red as your creation collapses healthcare systems. Every region requires a specific strategic path to maximize infection yield and bypass localized defenses in real-time.
CORE FEATURES
Pathogens: Master prestige mechanics for Viruses, Bacteria, Fungi, and Nanobots.
AFK Gains: Progress continues with substantial offline rewards.
Dynamic Meta: Adapt to news, lockdowns, and global cure efforts.
Can you engineer the ultimate extinction event? The evolution begins now.
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